PowerPoint Presentation - Differential regulation of Id1, Id2, andTwist in myogenesis and osteogenesis

Twist-1
obHLH transcription factor
oHomodimer or heterodimer with other bHLHproteins (i.e.E proteins)
oRegulates cellmovement and mesoderm development during earlyembryogenesis (i.e. bone andmuscle)
oTwist-1has both positive and negative functions regulating mesenchymal celldifferentiation
oBindsto a conserved E-box sequence (CANNTG) on the promoter region that activates orinhibits transcription of a target gene
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