PowerPoint Presentation - Differential regulation of Id1, Id2, andTwist in myogenesis and osteogenesis

Twist-1
obHLH transcription factor
oHomodimer or heterodimer with other bHLH proteins (i.e. E proteins)
oRegulates cell movement and mesoderm development during earlyembryogenesis (i.e. bone and muscle)
oTwist-1 has both positive and negative functions regulating mesenchymal cell differentiation
oBinds to a conserved E-box sequence (CANNTG) on the promoter region that activates or inhibits transcription of a target gene

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