PowerPoint Presentation - Differential regulation of Id1, Id2, andTwist in myogenesis and osteogenesis

StudyÕs Model System
oNormal human cells undergo a limited number of cell divisions in culture
oEnter senescence, a non-dividing state

oTelomere shortening has been linked to cellular senescence

oRetroviral transduction of human telomerase reverse transcriptase (hTERT)
oMaintains telomere length
oExtends life span

oDr. GlackinÕs lab at COH created a human fetal mesenchymal stem cell linethat has been immortalized by the hTERTgene, hfMSC-SK-hTERT cell line
Mol Biol Cell, 2005, 16:1491-1499