PowerPoint Presentation - Differential regulation of Id1, Id2, andTwist in myogenesis and osteogenesis

Significance of Study
oDifferent members of the Id family are overexpressed in differenttumor types
oAbnormally high expression of Twist-1 in cancer cells has beenassociated with metastasis
oInvasive breast cancer
oTwist-1 overexpression prevents normal bone and muscledevelopment
oThe molecular basis of mechanisms that induce the differentiatedosteoblastic phenotype is poorlyunderstood