Friday, April 18, 2008
Personality disorder symptomatology and neuropsychological performance in HIV+ adults
Personality disorders (PDs) have generally received less attention in the literature on the neuropsychiatry of HIV. The present study examines the association between personality disorder symptomatology and neuropsychological (NP) performance in a sample of 276 HIV seropositive adults. It was hypothesized that higher symptomatology on schizotypal, antisocial, and borderline personality disorder scales will be associated with poorer neuropsychological performance. PD symptomatology was indexed using the MCMI-III. NP performance was indexed via 7 composite scores assessing information processing, attention, learning, executive function, verbal fluency, motor speed, and global performance. Results reveal personality symptomatology to be negatively associated with the NP deficits, specifically: schizoid with information processing, learning and global functioning (p’s< .05); paranoid with information processing, learning, attention, executive function, and global performance (p’s< .05); schizotypal with executive function(p< .05), avoidant with information processing, attention, executive function, and global performance (p’s< .05) , and dependent symptoms with attention (p< .05). This preliminary investigation suggests that PD symptomatology may confer further deleterious effects on NP performance above and beyond other CNS neurotoxicities. Further work examining mechanisms by which the PDs impact NP function in HIV, as well as possible interactive effects between PD and HIV on NP performance is needed.