Friday, May 16, 2008
Cell surface protein display in Gram positive bacteria
Robert T. Clubb, Associate Professor of Biochemistry, UC Los Angeles
The emergence of multi-drug resistance bacteria has highlighted the growing need for new antimicrobial compounds that target novel aspects of microbial physiology. Surface proteins in Gram-positive pathogens are frequently required for virulence, and research in the past decade has revealed that a large fraction of these proteins are covalently anchored to the cell wall by sortase enzymes. We are trying to use structure based approaches to rationally design a therapeutically useful inhibitor of cell wall protein anchoring. In this seminar I will discuss recent progress towards understanding themechanism of catalysis.