Spring 2012 Biomedical Seminar Series
June 1, 2012
Accelerated CÂH Activation Reactions:
A Shortcut to Molecular Complexity from Chemical Feedstock
Department of Chemistry
The Scripps Research Institute
10550 N. Torrey Pines Road
BCC-372, La Jolla, California, 92037-1000, U.S.A.
Pd(II)-catalyzed enantioselective and position-selective CÂH activation reactions are developed using mono-N-protected chiral amino acid ligands. CÂH activation intermediates are characterized, offering insights into the origin of the observed stereoselectivity. Most importantly, these chiral ligands are found to accelerate drastically CÂH activation reactions, shortening the reaction time from two days to 20 minutes.