MORE Programs Poster Presentation
October 13, 2006
Oliver Hankinson, Ph.D.
Mechanisms of carcinogenesis by dioxin and other environmental carcinogens. Opportunities in the doctoral program in Molecular Toxicology at UCLA.
My research group focuses on several areas relevant to chemical induction of cancer and chemopreventon of cancer. i) We are studying the roles of coactivator proteins and chromatin modification during the induction of the CYP1A1 and CYP1B1 genes by dioxin and polycyclic aromatic hydrocarbon (PAH) pollutants. ii) We are investigating these same parameters during induction of the erythropoietin gene by hypoxia. iii) We are studying the role of the aryl hydrocarbon receptor nuclear translocator protein in cancer induction by dioxin and PAH in the mouse. iv) We are studying the role of a new cytochrome P450 that we discovered, CYP2S1, in the susceptibility of mammals to toxic compounds. v) We are investigating the mechanisms whereby certain compounds found in common vegetables (phytochemicals) protect against cancer.
Molecular Toxicology: http://www.pathnet.medsch.ucla.edu/educ/Mol%20Tox/index.htm