PowerPoint Presentation - Differential regulation of Id1, Id2, andTwist in myogenesis and osteogenesis

StudyÕs Model System
oNormal human cellsundergo a limited number of cell divisions inculture
oEnter senescence, a non-dividing state
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oTelomere shortening hasbeen linked to cellular senescence
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oRetroviraltransduction of human telomerase reverse transcriptase(hTERT)
oMaintains telomere length
oExtends life span
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oDr. GlackinÕs lab at COHcreated a human fetal mesenchymal stem cellline that has been immortalized by the hTERTgene, hfMSC-SK-hTERT cell line
MolBiol Cell, 2005, 16:1491-1499