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Richard Murray, Ph.D. - Tuesday, April 5, 2011
Professor of Control & Dynamical Systems & Bioengineering
California Institute of Technology
Feedback & Control in Biological Circuit Design
Biological systems make use of feedback in an extraordinary number of ways, on scales ranging from molecules to cells to organisms to ecosystems. In this talk I will discuss the use of concepts from control and dynamical systems in the analysis and design of biological feedback circuits at the molecular level. After a brief survey of relevant concepts from synthetic biology, I will present some recent results that combine modeling, identification, design and experimental implementation of biological feedback circuits. These results include the use of intrinsic noise for system identification in transcriptional regulatory networks, development of an in vitro circuit for regulating the rates of transcription of two independent genetic sequences, and design of dynamics of for an in vivo oscillator using transcriptional delay. Using these results as examples, I will discuss some of the open problems and research challenges in the area feedback control using biological circuits.
Time: 12:10-1:00 p.m. in Biological Sciences Room 335.
Kevin Squire , Ph.D. - Tuesday, May 17, 2011
Postdoctoral Fellow, Department of Human Genetics
University of California, Los Angeles
Using 2nd Generation Sequencing Technology to Study the Genetics of Human Disease
The Human Genome Project produced the first draft sequence of the human genome 10 years ago. The availability of this sequence, coupled with new sequencing technology and bioinformatics tools, is poised to change the way medicine is conducted. In the Nelson Laboratory in the Department of Human Genetics at UCLA, we are using 2nd generation sequencing technology to study the genetics of human diseases, including autism, cancer, and rare Mendelian disorders. In this talk, I will give an overview of capabilities and limitations the technology we use, discuss the general and specific goals of some of our research, and then describe the a specific study of the genetic changes in a tumor from a patient with glioblastoma.
Time: 12:10-1:00 p.m. in Biological Sciences Room 335. Back to Top
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