I first came to CSULA as a freshman majoring in Computer Science and Mathematics. After I earned my B.S. and M.S. from CSULA, I decided to pursue my Ph.D. at University of California, Santa Barbara. While doing my graduate study, I became hooked on Mathematical Biology and in particular Computational Biomodeling as it combines applied math, computer science, and my lifelong interest in biology. I completed my dissertation in 2009 and I am happy to come back to CSULA to work with the students and faculty here.
- Mathematical Biology
My research work in Mathematical Biology focuses on developing a computer simulations of biological systems to understand how biological entities, such as cells, grow and work collectively to ensure their survivals in changing environments. My current work deals with developing a multiscale agent-based model for tumor growth and its progression into cancer. The long-term goal of this research is to investigate the use of mesenchymal stem cells as therapeutic agents that promote tumor cell death.
In the past I have also developed a bioenergetic-based computational model to study the social behavior and self-coordination in bacteria by using myxobacteria as a model system. The model simulates the swarming behavior of myxobacteria and the phase transition in their life cycle. With this model we determine essential parameters and the consequences on the mutant cells.
- Optimization Theory
My research in the Optimization Theory focuses on Newton-type hybrid algorithms for solving a system of nonlinear equations and function minimization.
SELECTED RESEARCH ARTICLES
- Hendrata, M. and Sudiono, J., A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome, Computational and Mathematical Methods in Medicine, Vol. 2016, Article ID 4910603, 2016. doi: 10.1155/2016/4910603.
- Hendrata, M. and Subramanian, P. K., Nonmonotone Convergence and Relaxing Functions, Int. Journal of Pure and Applied Math, Vol. 83 No. 2, 349-364, 2013.
- Hendrata, M. and Subramanian, P. K., Alternatives to trigonometric substitutions, Pi Mu Epsilon Journal, Vol. 13 No. 7, 401-406, 2012.
- Hendrata, M. and Subramanian, P. K., Some Remarks on Newton's Algorithm - II, Int. Journal of Pure and Applied Math, Vol. 74 No. 3, 373-391, 2012.
- Hendrata, M., Yang, Z. Lux, R., and Shi, W., Experimentally Guided Computational Model Discovers Important Elements for Social Behavior in Myxobacteria, PLoS ONE, Vol. 6, Issue 7, e22169, 2011.
- Hendrata, M. and Subramanian, P. K., Some Remarks on Newton's Algorithm, Int. Journal of Pure and Applied Math, Vol. 63 No. 2, 223-241, 2010.
- Hendrata, M. and Birnir, B., Dynamic-Energy-Budget-driven fruiting-body formation in Myxobacteria, Physical Review E, Vol. 81, 061902, 2010.
- Lecture Notes on Ordinary Differential Equations (with P. K. Subramanian) 4th. ed., 2017.
- Ph.D. Mathematics (2009), University of California, Santa Barbara
- M.A. Applied Math (2008), University of California, Santa Barbara
- M.S. Mathematics (2004), CSULA
- B.S. Computer Science and Mathematics (2002), CSULA